A successful HIV vaccine should elicit protective antibodies, and the combination of B cell and CD4+ T cell responses is critical for the induction and long-term maintenance of vaccine protection. It is crucial to define immunogens and immunization regimens that induce protective B cell and CD4+ T cell responses in preclinical models and thereby guide product development strategies for a preventive human AIDS vaccine.
We propose integrated efforts focused on two areas: (1) B cell and antibody research to guide the development of immunogens and immunization regimes that elicit protective HIV antibody responses and (2) CD4+ T cell research, taking advantage of key preliminary data to maximize the T cell help offered to B cell responses through immunization, and to harness the direct antiviral activity of CD4+ T cells. Therefore, the Scripps CHAVI-ID is divided into two research focus areas and five Scientific Research Support Components (SRSCs).
- Research Focus #1 concentrates on B cell and antibody research to guide the development of immunogens that elicit protective HIV antibody responses in appropriate animal models. Click the link above to learn more about our targeted goals in this area.
- Research Focus #2 concentrates on CD4+ T cell research, taking advantage of key preliminary data to maximize the T cell help offered to B cell responses through immunization, and to harness the direct antiviral activity of CD4+ T cells. Click the link above to learn more about our targeted goals in this area. .
Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date and the world still awaits an HIV vaccine. Achievement of the overall goals of the Scripps CHAVI-ID will require that investigators working on the two Foci interact effectively to ensure that information flows efficiently in both directions and understanding can be translated into improvements in immunogens and immunization strategies. There is a high degree of interconnectivity within and between the Foci and a desire to advance these efforts though collaborations with investigators outside the Center and around the world.
The five Scientific Research Support Components (SRSCs) provide essential services to the research Foci.
- Operations and Management SRSC lead by the CHAVI-ID Director, Dennis Burton; Science Officer, Salvatore Butera; and Administrative Officer, Joan Allmaras. This unit supports both Foci to facilitate their interaction and integration within the Center.
- Vaccine Discovery SRSC coordinated by Julie McElrath as a small, integrated scientific body with broad expertise in vaccine development that will act initially in an advisory capacity to the CHAVI-ID leadership. As immunogens and immunization regimes are discovered, this group will provide valuable guidance, based on individual experience, toward identifying immunogens that can be successfully formulated for licensure and administered safely.
- Non-human Primates SRSC directed by Dan Barouch and Guido Silvestri will provide support for immunization and protection
- Glycobiology SRSC lead by Max Crispin will focus on the analysis and optimization of glycans from CHAVI-ID immunogens and will contribute to Focus #1 Aims 1, 4, 5, and 6.
- Data Management SRSC coordinated by Adam Godzik will apply state-of-the-art informatics, bioinformatics, data management and biostatistical analyses to promote the design, conduct, analysis, and reporting of the projects that comprise the CHAVI-ID and maintain an integrated database for data collected by CHAVI-ID investigators.