Bruce Walker, MD is Director of the Ragon Institute of MGH, MIT and Harvard, a Professor of Medicine at Harvard Medical School, and a Howard Hughes Medical Institute Investigator. Dr Walker's principal interests include mechanisms of immune control in HIV infection, focusing in particular on persons who control HIV infection spontaneously without the need for medication (HIV controllers). This research has led to critical insights regarding the adaptive CD8 T cell responses to HIV. Dr Walker was also the first investigator to determine that HIV-specific CD4 T cell responses had a different functional profile in subjects with spontaneous viral control compared to individuals with progressive disease. Besides the research program conducted in Boston, Dr Walker also has close collaboration with the HIV-1 Pathogenesis Program at the Nelson Mandela School of Medicine at the University of KwaZulu-Natal in Durban, South Africa, in which he has been deeply involved since its creation. The studies conducted in this region at the heart of the HIV epidemic have yielded critical knowledge on HIV Clade C infection. Since the foundation of the Ragon Institute in 2009, Dr Walker has also spearheaded a major effort devoted to accelerating discovery of an HIV/AIDS vaccine and to the collaborative study of immunology. He is a member of the Institute of Medicine of the National Academy of Sciences, the American Society for Clinical Investigation, and the American Academy of Arts and Sciences. Dr. Walker is a member of the Scientific Leadership Group of the CHAVI-ID and the administrative leader of this effort at the Ragon Institute. He will oversee the clinical core involving human volunteers and acquisition of clinical samples for the research projects. In coordination with Dr Kaufmann, Dr Walker will oversee studies of immune responses in blood and tissues of HIV-infected individuals.