Daniel E. Kaufmann, MD is an Associate Professor of Medicine at the University of Montreal and a Principal Investigator at the University of Montreal Hospital Research Center (CRCHUM). Dr. Kaufmann is a physician scientist whose research focuses on the regulation of HIV-specific T cell function, with an emphasis on HIV-specific CD4 T cell (Thelper) cell responses. He has made important discoveries on the role that inhibitory pathways like PD-1, IL-10 and CTLA-4 play in HIV-specific T cell exhaustion, demonstrating that this impairment is to a significant extent under the control of active - and potentially reversible - mechanisms. Some areas of special current interest for the laboratory include the role of inhibitory receptors and transcription factors in the regulation of CD4 T cell function. Dr Kaufmann is studying the fine structure and function of the HIV-specific CD4 Thelper response in both peripheral blood and tissues, which requires the use of new experimental approaches. He is also seeking to establish novel immunomonitoring tools that integrate heterogeneous sets of immunological data on HIV-specific T cell phenotype and functions in order to identify protective components of the immune response to natural infection and vaccines. Dr Kaufmann serves as associate editor of the Journal of Immunology.
Dr. Kaufmann is principal investigator of the CHAVI-ID. Dr Kaufmann oversees studies of immune responses in blood and tissues of HIV-infected individuals and uninfected volunteers.