Dennis Burton, PhD has been a PI on NIH grants (RO1, R21, PO1) since 1991, having moved from the UK to the USA in 1989. He has worked on antibodies for some 35 years and on HIV for 20 years. He has co-authored 270 primary research papers, 70 peer-reviewed research reviews, 15 commentaries and letters, 45 book chapters and 2 textbooks. Of note, of the primary publications, 10 are in Science, 10 are in Nature, 4 are in Nature Medicine and 2 are in Immunity. For a 20-year period, his laboratory has maintained a position amongst the leaders in the exploration of antibodies and HIV and significance for vaccine design. He has pioneered studies on antibody protection against HIV/SHIV challenge in animal models. In particular, he first described a broadly neutralizing antibody to HIV (b12) (Burton et al, 1994), then antibody protection against primary isolate challenge in vivo (Gauduin et al, 1997), showed the importance of Fc receptor binding in antibody protection against HIV (Hessell et al, 2007), showed less antibody is required to protect against HIV than high-dose viral challenge (Hessell et al, 2009) and described highly potent broadly neutralizing antibodies (PG9/16 and PGT Abs to HIV (Walker et al, 2009; Walker et al, 2011).