Shane Crotty, PhD is an Associate Professor with tenure at the La Jolla Institute for Allergy and Immunology (LIAI), and is an adjunct Associate Professor in the UCSD Dept. of Medicine. His research focus is on understanding the immunobiology underlying vaccine function, with particular interest in the roles of these mechanisms in human viral vaccines and protection from infectious diseases. At University of California, San Francisco he discovered a mechanism of action of the antiviral drug ribavirin (Nat. Med. 2000, PNAS 2001), widely used to treat chronic hepatitis C infections. After working on an AIDS vaccine for several years (Nature 1999, J. Virology 1999, J. Virology 2001), Dr. Crotty came to the decision that we knew insufficient immunology for rational vaccine design. His focus since that point has been on taking the steps necessary to build the fundamental immunology knowledge needed for future rational vaccine design. Dr. Crotty completed postdoctoral work at the Emory University Vaccine Center with Dr. Rafi Ahmed, studying aspects of the generation and maintenance of immune memory after viral infections. Since 2003, his laboratory at LIAI has focused on understanding mechanisms of immunological memory (Nature 2003, J. Exp Med. 2006, J. Immunology 2007), the immunological basis for the development of protective neutralizing antibodies to the smallpox vaccine (J. Virology 2005, 2008, 2009, and 2009. Immunity 2008, Vaccine 2009), the interactions of B cells and CD4 T cells (Immunity 2008, Science 2009, Immunity 2011), and the development of follicular helper CD4 T cells (Science 2009, Immunity 2011, Annual Review of Immunology 2011).