Scripps CHAVI-ID Paper Makes Cover of Immunity

Similar to steering a spaceship through a dense asteroid field, the evolutionary pathway that leads a germline precursor antibody to develop broadly neutralizing activity against HIV-1 is filled with obstacles. In the April 19 issue of Immunity, Kong et al combine structural characterization, B cell repertoire sequencing, and single-genome amplification of viral population to identify the key obstacles in the evolution of antibodies that recognize the CD4-receptor binding site of the primary HIV-1 antigen, gp160, in a Chinese patient over a 5-year period. The study traces the early evolutionary pathways taken by one family of antibodies (DRVIA7). Receptor binding site proximal N-linked glycans are the key obstacles toward the evolution of broadly neutralizing activity.

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Immunity, by Christina Corbaci and Fernando Garces