Accelerating next-generation vaccine development for global disease prevention.

TitleAccelerating next-generation vaccine development for global disease prevention.
Publication TypeJournal Article
Year of Publication2013
AuthorsKoff WC, Burton DR, Johnson PR, Walker BD, King CR, Nabel GJ, Ahmed R, Bhan MK, Plotkin SA
JournalScience
Volume340
Issue6136
Pagination1232910
Date Published05/31/2013
ISSN1095-9203
KeywordsAcquired Immunodeficiency Syndrome, Adjuvants, Immunologic, Animals, Antigens, Communicable Disease Control, Disease Models, Animal, Drug Delivery Systems, Humans, Malaria, Tuberculosis, Vaccines
Abstract

Vaccines are among the greatest successes in the history of public health. However, past strategies for vaccine development are unlikely to succeed in the future against major global diseases such as AIDS, tuberculosis, and malaria. For such diseases, the correlates of protection are poorly defined and the pathogens evade immune detection and/or exhibit extensive genetic variability. Recent advances have heralded in a new era of vaccine discovery. However, translation of these advances into vaccines remains impeded by lack of understanding of key vaccinology principles in humans. We review these advances toward vaccine discovery and suggest that for accelerating successful vaccine development, new human immunology-based clinical research initiatives be implemented with the goal of elucidating and more effectively generating vaccine-induced protective immune responses.

DOI10.1126/science.1232910
Alternate JournalScience
PubMed ID23723240
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