Antibodies expose multiple weaknesses in the glycan shield of HIV.

TitleAntibodies expose multiple weaknesses in the glycan shield of HIV.
Publication TypeJournal Article
Year of Publication2013
AuthorsCrispin M, Bowden TA
JournalNat Struct Mol Biol
Volume20
Issue7
Pagination771-2
Date Published07/01/2013
ISSN1545-9985
KeywordsAntibodies, Neutralizing, HIV Antibodies, HIV Envelope Protein gp120, Humans, Peptide Fragments, Polysaccharides
Abstract

A shield of glycans coats the viral-envelope proteins of HIV. Recent work shows how broadly neutralizing antibodies can recognize this shield despite structural variation in these ‘self’ carbohydrate structures.

DOI10.1038/nsmb.2627
Alternate JournalNat. Struct. Mol. Biol.
PubMed ID23984441
Grant List090532 / / Wellcome Trust / United Kingdom
CHAVI-ID: 
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