Antibody responses to envelope glycoproteins in HIV-1 infection.

TitleAntibody responses to envelope glycoproteins in HIV-1 infection.
Publication TypeJournal Article
Year of Publication2015
AuthorsBurton DR, Mascola JR
JournalNat Immunol
Volume16
Issue6
Pagination571-6
Date Published06/01/2015
ISSN1529-2916
KeywordsAIDS Vaccines, Animals, Antibodies, Neutralizing, Antibody Formation, Disease Models, Animal, env Gene Products, Human Immunodeficiency Virus, HIV Antibodies, HIV Infections, HIV-1, Humans, Immunotherapy
Abstract

Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups. Binding but non-neutralizing responses are directed to epitopes that are expressed on isolated envelope glycoproteins but not on the native envelope trimer found on the surface of virions and responsible for mediating the entry of virus into target cells. Strain-specific responses and broadly neutralizing responses, in contrast, target epitopes that are expressed on the native trimer, as revealed by recently resolved structures. The past few years have seen the isolation of many broadly neutralizing antibodies of remarkable potency that have shown prophylactic and therapeutic activities in animal models. These antibodies are helping to guide rational vaccine design and therapeutic strategies for HIV-1.

DOI10.1038/ni.3158
Alternate JournalNat. Immunol.
PubMed ID25988889
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
/ / Intramural NIH HHS / United States
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