Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory.

TitleBcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory.
Publication TypeJournal Article
Year of Publication2013
AuthorsChoi YSoo, Yang JA, Yusuf I, Johnston RJ, Greenbaum J, Peters B, Crotty S
JournalJ Immunol
Volume190
Issue8
Pagination4014-26
Date Published04/15/2013
ISSN1550-6606
Abstract

Follicular helper CD4 T (Tfh) cells are a distinct type of differentiated CD4 T cells uniquely specialized for B cell help. In this study, we examined Tfh cell fate commitment, including distinguishing features of Tfh versus Th1 proliferation and survival. Using cell transfer approaches at early time points after an acute viral infection, we demonstrate that early Tfh cells and Th1 cells are already strongly cell fate committed by day 3. Nevertheless, Tfh cell proliferation was tightly regulated in a TCR-dependent manner. The Tfh cells still depend on extrinsic cell fate cues from B cells in their physiological in vivo environment. Unexpectedly, we found that Tfh cells share a number of phenotypic parallels with memory precursor CD8 T cells, including selective upregulation of IL-7Rα and a collection of coregulated genes. As a consequence, the early Tfh cells can progress to robustly form memory cells. These data support the hypothesis that CD4 and CD8 T cells share core aspects of a memory cell precursor gene expression program involving Bcl6, and a strong relationship exists between Tfh cells and memory CD4 T cell development.

DOI10.4049/jimmunol.1202963
Alternate JournalJ. Immunol.
PubMed ID23487426
PubMed Central IDPMC3626566
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