A brief history of T cell help to B cells.

TitleA brief history of T cell help to B cells.
Publication TypeJournal Article
Year of Publication2015
AuthorsCrotty S
JournalNat Rev Immunol
Volume15
Issue3
Pagination185-9
Date Published03/01/2015
ISSN1474-1741
Abstract

In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+) T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.

DOI10.1038/nri3803
Alternate JournalNat. Rev. Immunol.
PubMed ID25677493
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
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