Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.

Tue, 09/04/2012 - 4:18pm -- dana
TitleBroadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
Publication TypeJournal Article
Year of Publication2012
AuthorsBurton DR, Poignard P, Stanfield RL, Wilson IA
JournalScience
Volume337
Issue6091
Pagination183-6
Date Published2012 Jul 13
ISSN1095-9203
KeywordsAIDS Vaccines, Animals, Antibodies, Neutralizing, Antibodies, Viral, Antigenic Variation, Drug Discovery, env Gene Products, Human Immunodeficiency Virus, Hepacivirus, Hepatitis C, HIV Antibodies, HIV Infections, HIV-1, Humans, Influenza Vaccines, Influenza, Human, Models, Molecular, Orthomyxoviridae
Abstract

Certain human pathogens avoid elimination by our immune system by rapidly mutating the surface protein sites targeted by antibody responses, and consequently they tend to be problematic for vaccine development. The behavior described is prominent for a subset of viruses--the highly antigenically diverse viruses--which include HIV, influenza, and hepatitis C viruses. However, these viruses do harbor highly conserved exposed sites, usually associated with function, which can be targeted by broadly neutralizing antibodies. Until recently, not many such antibodies were known, but advances in the field have enabled increasing numbers to be identified. Molecular characterizations of the antibodies and, most importantly, of the sites of vulnerability that they recognize give hope for the discovery of new vaccines and drugs.

DOI10.1126/science.1225416
Alternate JournalScience
PubMed ID22798606