CD4+ T cells and HIV: A paradoxical Pas de Deux.

TitleCD4+ T cells and HIV: A paradoxical Pas de Deux.
Publication TypeJournal Article
Year of Publication2012
AuthorsKlatt NR, Silvestri G
JournalSci Transl Med
Volume4
Issue123
Pagination123ps4
Date Published2012 Feb 29
ISSN1946-6242
KeywordsCD4-Positive T-Lymphocytes, HIV Infections, HIV-1, Humans
Abstract

When it comes to HIV infection, CD4(+) T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4(+) T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4(+) T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.

DOI10.1126/scitranslmed.3003862
Alternate JournalSci Transl Med
PubMed ID22378922