Computational tools for epitope vaccine design and evaluation.

TitleComputational tools for epitope vaccine design and evaluation.
Publication TypeJournal Article
Year of Publication2015
AuthorsHe L, Zhu J
JournalCurr Opin Virol
Volume11
Pagination103-112
Date Published04/01/2015
ISSN1879-6265
Abstract

Rational approaches will be required to develop universal vaccines for viral pathogens such as human immunodeficiency virus, hepatitis C virus, and influenza, for which empirical approaches have failed. The main objective of a rational vaccine strategy is to design novel immunogens that are capable of inducing long-term protective immunity. In practice, this requires structure-based engineering of the target neutralizing epitopes and a quantitative readout of vaccine-induced immune responses. Therefore, computational tools that can facilitate these two areas have played increasingly important roles in rational vaccine design in recent years. Here we review the computational techniques developed for protein structure prediction and antibody repertoire analysis, and demonstrate how they can be applied to the design and evaluation of epitope vaccines.

DOI10.1016/j.coviro.2015.03.013
Alternate JournalCurr Opin Virol
PubMed ID25837467
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
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