Dynamics of lentiviral infection in vivo in the absence of adaptive immune responses.

Mon, 04/30/2018 - 10:07am -- dana
TitleDynamics of lentiviral infection in vivo in the absence of adaptive immune responses.
Publication TypeJournal Article
Year of Publication2018
AuthorsSchwartz EJ, Vaidya NK, Dorman KS, Carpenter S, Mealey RH
Date Published2018 01 01
KeywordsAnimals, Antibodies, Neutralizing, Antibodies, Viral, Equine Infectious Anemia, Horses, Infectious Anemia Virus, Equine, Models, Theoretical, Severe Combined Immunodeficiency, Viral Load

Understanding the dynamics of acute viral infection is crucial for developing strategies to prevent and control infection. In this study, lentiviral dynamics in a host without adaptive immunity were examined in order to determine kinetic parameters of infection and quantify the effect of neutralizing antibodies in preventing infection, using mathematical modeling of data from equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Estimated parameters were used to calculate the basic reproductive number and virus doubling time and found that the rate that antibodies neutralized virus was ~18 times greater than the virus clearance rate. These results establish EIAV replication kinetics in SCID horses and the minimal efficacy of antibodies that blocked infection. Furthermore, they indicate that EIAV is at most mildly cytopathic. This study advances our understanding of EIAV infection and may have important implications for the control of other viral infections, including HIV.

Alternate JournalVirology
PubMed ID29055819