Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.

TitleFollicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.
Publication TypeJournal Article
Year of Publication2015
AuthorsHeesters BA, Lindqvist M, Vagefi PA, Scully EP, Schildberg FA, Altfeld M, Walker BD, Kaufmann DE, Carroll MC
JournalPLoS Pathog
Volume11
Issue12
Paginatione1005285
Date Published12/01/2015
ISSN1553-7374
Abstract

Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ FDC with a soluble complement receptor 2 purges the FDC of HIV virions and prevents viral transmission in vitro. Our results provide an explanation for how FDC can retain infectious HIV for extended periods and suggest a therapeutic strategy to achieve cure in HIV-infected humans.

DOI10.1371/journal.ppat.1005285
Alternate JournalPLoS Pathog.
PubMed ID26623655
PubMed Central IDPMC4666623
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
CHAVI-ID: 
1
Cover Picture: