|Title||Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Heesters BA, Lindqvist M, Vagefi PA, Scully EP, Schildberg FA, Altfeld M, Walker BD, Kaufmann DE, Carroll MC|
Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ FDC with a soluble complement receptor 2 purges the FDC of HIV virions and prevents viral transmission in vitro. Our results provide an explanation for how FDC can retain infectious HIV for extended periods and suggest a therapeutic strategy to achieve cure in HIV-infected humans.
|Alternate Journal||PLoS Pathog.|
|PubMed Central ID||PMC4666623|
|Grant List||UM1 AI100663 / AI / NIAID NIH HHS / United States|
Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.