|Title||Harnessing CD4(+) T cell responses in HIV vaccine development.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Streeck H, D'Souza PM, Littman DR, Crotty S|
CD4(+) T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4(+) T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4(+) T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4(+) T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4(+) T cells in other aspects of protective immunity. Here we discuss whether CD4(+) T cell responses may represent a beneficial component of an efficacious HIV vaccine.
|Alternate Journal||Nat. Med.|
Harnessing CD4(+) T cell responses in HIV vaccine development.