Harnessing CD4(+) T cell responses in HIV vaccine development.

TitleHarnessing CD4(+) T cell responses in HIV vaccine development.
Publication TypeJournal Article
Year of Publication2013
AuthorsStreeck H, D'Souza PM, Littman DR, Crotty S
JournalNat Med
Volume19
Issue2
Pagination143-9
Date Published02/01/2013
ISSN1546-170X
Abstract

CD4(+) T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4(+) T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4(+) T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4(+) T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4(+) T cells in other aspects of protective immunity. Here we discuss whether CD4(+) T cell responses may represent a beneficial component of an efficacious HIV vaccine.

DOI10.1038/nm.3054
Alternate JournalNat. Med.
PubMed ID23389614
CHAVI-ID: 
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