Human Circulating PD-1(+) CXCR3(-) CXCR5(+) Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses.

TitleHuman Circulating PD-1(+) CXCR3(-) CXCR5(+) Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses.
Publication TypeJournal Article
Year of Publication2013
AuthorsLocci M, Havenar-Daughton C, Landais E, Wu J, Kroenke MA, Arlehamn CL, Su LF, Cubas R, Davis MM, Sette A, Haddad EK, Poignard P, Crotty S
Corporate AuthorsInternational AIDS Vaccine Initiative Protocol C Principal Investigators
JournalImmunity
Date Published10/17/2013
ISSN1097-4180
Abstract

The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. It is now conceivable that an antibody-dependent HIV vaccine might be possible, given the discovery of HIV broadly neutralizing antibodies (bnAbs) in some HIV-infected individuals. However, these antibodies are difficult to develop and have characteristics indicative of a high degree of affinity maturation in germinal centers (GCs). CD4(+) T follicular helper (Tfh) cells are specialized for B cell help and necessary for GCs. Therefore, the development of HIV bnAbs might depend on Tfh cells. Here, we identified in normal individuals a subpopulation of circulating memory PD-1(+)CXCR5(+)CD4(+) T cells that are resting memory cells most related to bona fide GC Tfh cells by gene expression profile, cytokine profile, and functional properties. Importantly, the frequency of these cells correlated with the development of bnAbs against HIV in a large cohort of HIV(+) individuals.

DOI10.1016/j.immuni.2013.08.031
Alternate JournalImmunity
PubMed ID24035365
CHAVI-ID: 
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