Identification of HIV-1-specific regulatory T cells using HLA class II tetramers.

TitleIdentification of HIV-1-specific regulatory T cells using HLA class II tetramers.
Publication TypeJournal Article
Year of Publication2012
AuthorsAngin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM
JournalAIDS
Date Published2012 Aug 7
ISSN1473-5571
Abstract

Regulatory T cells (Tregs) are potent immune modulators, but their precise role in HIV pathogenesis remains incompletely understood. Most studies to date have focused on frequencies or phenotypes of "bulk" Treg populations. However, while antigen-specific Tregs have been reported in other diseases, HIV-1-epitope specific Tregs have not been described to date. We here report the first identification of functional HIV-1-Gag-specific regulatory T cells using HLA class II tetramer staining in HIV-1-infected individuals.

DOI10.1097/QAD.0b013e328358cc75
Alternate JournalAIDS
PubMed ID22874519