|Title||Identification of HIV-1-specific regulatory T cells using HLA class II tetramers.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Angin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM|
|Date Published||2012 Aug 7|
Regulatory T cells (Tregs) are potent immune modulators, but their precise role in HIV pathogenesis remains incompletely understood. Most studies to date have focused on frequencies or phenotypes of "bulk" Treg populations. However, while antigen-specific Tregs have been reported in other diseases, HIV-1-epitope specific Tregs have not been described to date. We here report the first identification of functional HIV-1-Gag-specific regulatory T cells using HLA class II tetramer staining in HIV-1-infected individuals.