Immune complexes: not just an innocent bystander in chronic viral infection.

TitleImmune complexes: not just an innocent bystander in chronic viral infection.
Publication TypeJournal Article
Year of Publication2015
AuthorsWang TT, Ravetch JV
JournalImmunity
Volume42
Issue2
Pagination213-5
Date Published2015 Feb 17
ISSN1097-4180
Abstract

Understanding of how persistent viral infection impacts humoral immunity is incomplete. In this issue of Immunity, Wieland et al. (2015) and Yamada et al. (2015) find that high amounts of IgG-antigen complexes formed during chronic lymphocytic choriomeningitis infection can interfere with Fcγ-receptor-mediated effector activities, potentially contributing to immune dysfunction.

DOI10.1016/j.immuni.2015.01.022
Alternate JournalImmunity
PubMed ID25692698
Grant ListKL2TR000151 / TR / NCATS NIH HHS / United States
UL1 TR000043 / TR / NCATS NIH HHS / United States
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