Immunologic strategies for HIV-1 remission and eradication.

TitleImmunologic strategies for HIV-1 remission and eradication.
Publication TypeJournal Article
Year of Publication2014
AuthorsBarouch DH, Deeks SG
JournalScience
Volume345
Issue6193
Pagination169-74
Date Published07/11/2014
ISSN1095-9203
Abstract

Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these drugs, and are motivated to take them daily for life. However, ART is not curative. HIV-1 persists indefinitely during ART as quiescent integrated DNA within memory CD4(+) T cells and perhaps other long-lived cellular reservoirs. In this Review, we discuss the role of the immune system in the establishment and maintenance of the latent HIV-1 reservoir. A detailed understanding of how the host immune system shapes the size and distribution of the viral reservoir should lead to the development of a new generation of immune-based therapeutics, which may eventually contribute to a curative intervention.

DOI10.1126/science.1255512
Alternate JournalScience
PubMed ID25013067
PubMed Central IDPMC4096716
Grant ListAI078526 / AI / NIAID NIH HHS / United States
AI084794 / AI / NIAID NIH HHS / United States
AI095985 / AI / NIAID NIH HHS / United States
AI096040 / AI / NIAID NIH HHS / United States
AI096109 / AI / NIAID NIH HHS / United States
AI100663 / AI / NIAID NIH HHS / United States
OD011170 / OD / NIH HHS / United States
R01 AI084794 / AI / NIAID NIH HHS / United States
R01 OD011170 / OD / NIH HHS / United States
U19 AI078526 / AI / NIAID NIH HHS / United States
U19 AI095985 / AI / NIAID NIH HHS / United States
U19 AI096040 / AI / NIAID NIH HHS / United States
UM1 AI100663 / AI / NIAID NIH HHS / United States
CHAVI-ID: 
1
Cover Picture: