Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.

TitleLack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.
Publication TypeJournal Article
Year of Publication2012
AuthorsWright JK, Brumme ZL, Julg B, van der Stok M, Mncube Z, Gao X, Carlson JM, Goulder PJR, Walker BD, Brockman MA, Ndung'u T
JournalJ Virol
Volume86
Issue2
Pagination1273-6
Date Published01/2012
ISSN1098-5514
KeywordsAlleles, CD4-Positive T-Lymphocytes, gag Gene Products, Human Immunodeficiency Virus, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, HIV Infections, HIV-1, Humans, Peptide Hydrolases, Virus Replication
Abstract

It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles and lower replication capacity, suggesting no significant HIV-1 attenuation by HLA class II-restricted Gag-specific CD4(+) T cell immune pressure.

DOI10.1128/JVI.06533-11
Alternate JournalJ. Virol.
PubMed ID22090116
PubMed Central IDPMC3255856
Grant ListN0IAI-15422 / / PHS HHS / United States
P30 AI060354 / AI / NIAID NIH HHS / United States
R01 AI046995 / AI / NIAID NIH HHS / United States
R0I-AI067073 / AI / NIAID NIH HHS / United States
R37 AI067073 / AI / NIAID NIH HHS / United States
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