Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.

TitleModulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.
Publication TypeJournal Article
Year of Publication2013
AuthorsHu J, Havenar-Daughton C, Crotty S
JournalCurr Opin Virol
Date Published06/01/2013
ISSN1879-6265
Abstract

Generating long-term humoral immunity is a crucial component of successful vaccines and requires interactions between T cells and B cells in germinal centers (GC). In GCs, a specialized subset of CD4(+) helper T cells, called T follicular helper cells (Tfh), provide help to B cells; this help directs the magnitude and quality of the antibody response. Tfh cell help influences B cell survival, proliferation, somatic hypermutation, class switch recombination, and differentiation. Sustained contact between Tfh cells and B cells is necessary for the provision of help to B cells. SAP (Signaling lymphocytic activation molecule (SLAM)-associated protein, encoded by Sh2d1a) regulates the duration of T:B cell interactions and is required for long-term humoral immunity in animal models and in humans. SAP binds to SLAM family receptors and mediates signaling that affects cell adhesion, cytokine secretion, and TCR signaling strength. Therefore, the modulation of SAP and SLAM family receptor expression represents a major axis by which the quality and duration of an antibody response is controlled after vaccination.

DOI10.1016/j.coviro.2013.05.015
Alternate JournalCurr Opin Virol
PubMed ID23743125
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
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