|Title||Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, Kasturi S, Carlone GM, Quinn C, Chaussabel D, A Palucka K, Mulligan MJ, Ahmed R, Stephens DS, Nakaya HI, Pulendran B|
Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.
|Alternate Journal||Nat. Immunol.|
|Grant List||P51 RR000165 / RR / NCRR NIH HHS / United States |
R01 DK057665 / DK / NIDDK NIH HHS / United States
R37 AI048638 / AI / NIAID NIH HHS / United States
R37 DK057665 / DK / NIDDK NIH HHS / United States
U19 AI057266 / AI / NIAID NIH HHS / United States
U19 AI090023 / AI / NIAID NIH HHS / United States
U19 AI096187 / AI / NIAID NIH HHS / United States
U54 AI057157 / AI / NIAID NIH HHS / United States
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.