Native functionality and therapeutic targeting of arenaviral glycoproteins.

TitleNative functionality and therapeutic targeting of arenaviral glycoproteins.
Publication TypeJournal Article
Year of Publication2016
AuthorsCrispin M, Zeltina A, Zitzmann N, Bowden TA
JournalCurr Opin Virol
Volume18
Pagination70-75
Date Published06/01/2016
ISSN1879-6265
Abstract

Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, the natural immune response, and immunoglobulin-based therapeutics. Arenaviral glycoprotein-mediated assembly and infection pathways present numerous opportunities and challenges for therapeutic intervention.

DOI10.1016/j.coviro.2016.04.001
Alternate JournalCurr Opin Virol
PubMed ID27104809
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
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