Polyreactive antibodies in adaptive immune responses to viruses.

TitlePolyreactive antibodies in adaptive immune responses to viruses.
Publication TypeJournal Article
Year of Publication2012
AuthorsMouquet H, Nussenzweig MC
JournalCell Mol Life Sci
Volume69
Issue9
Pagination1435-45
Date Published2012 May
ISSN1420-9071
KeywordsAdaptive Immunity, AIDS Vaccines, Antibodies, Viral, Antibody Affinity, Antibody Specificity, B-Lymphocytes, HIV Antibodies, HIV Infections, Host-Pathogen Interactions, Humans, Immune Tolerance, Immunity, Humoral, Immunity, Innate, Virus Diseases, Viruses
Abstract

B cells express immunoglobulins on their surface where they serve as antigen receptors. When secreted as antibodies, the same molecules are key elements of the humoral immune response against pathogens such as viruses. Although most antibodies are restricted to binding a specific antigen, some are polyreactive and have the ability to bind to several different ligands, usually with low affinity. Highly polyreactive antibodies are removed from the repertoire during B-cell development by physiologic tolerance mechanisms including deletion and receptor editing. However, a low level of antibody polyreactivity is tolerated and can confer additional binding properties to pathogen-specific antibodies. For example, high-affinity human antibodies to HIV are frequently polyreactive. Here we review the evidence suggesting that in the case of some pathogens like HIV, polyreactivity may confer a selective advantage to pathogen-specific antibodies.

DOI10.1007/s00018-011-0872-6
Alternate JournalCell. Mol. Life Sci.
PubMed ID22045557