|Title||Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Sliepen K, Ozorowski G, Burger JA, van Montfort T, Stunnenberg M, LaBranche C, Montefiori DC, Moore JP, Ward AB, Sanders RW|
BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation.
FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins.
CONCLUSIONS: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.
|PubMed Central ID||PMC4583754|
|Grant List||P01 AI082362 / AI / NIAID NIH HHS / United States |
UM1 AI100663 / AI / NIAID NIH HHS / United States
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.