Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.

TitlePresenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
Publication TypeJournal Article
Year of Publication2015
AuthorsSliepen K, Ozorowski G, Burger JA, van Montfort T, Stunnenberg M, LaBranche C, Montefiori DC, Moore JP, Ward AB, Sanders RW
JournalRetrovirology
Volume12
Pagination82
Date Published09/26/2015
ISSN1742-4690
Abstract

BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation.

FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins.

CONCLUSIONS: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.

DOI10.1186/s12977-015-0210-4
Alternate JournalRetrovirology
PubMed ID26410741
PubMed Central IDPMC4583754
Grant ListP01 AI082362 / AI / NIAID NIH HHS / United States
UM1 AI100663 / AI / NIAID NIH HHS / United States
CHAVI-ID: 
1
Cover Picture: