Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.

TitlePreserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
Publication TypeJournal Article
Year of Publication2012
AuthorsAngin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, Law KM, Hongo TC, Pyo A, Piechocka-Trocha A, Toth I, Pereyra F, Ghebremichael M, Rodig SJ, Milner DA, Richter JM, Altfeld M, Kaufmann DE, Walker BD, Addo MM
JournalJ Infect Dis
Volume205
Issue10
Pagination1495-500
Date Published2012 May 15
ISSN1537-6613
KeywordsCase-Control Studies, Chronic Disease, Cohort Studies, Disease Progression, Flow Cytometry, HIV Infections, HIV-1, Humans, Lymphocyte Count, Lymphoid Tissue, RNA, Viral, T-Lymphocytes, Regulatory, Viral Load
Abstract

Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.

DOI10.1093/infdis/jis236
Alternate JournalJ. Infect. Dis.
PubMed ID22427677