Prospects for a Zika Virus Vaccine.

TitleProspects for a Zika Virus Vaccine.
Publication TypeJournal Article
Year of Publication2017
AuthorsBarouch DH, Thomas SJ, Michael NL
JournalImmunity
Volume46
Issue2
Pagination176-182
Date Published02/21/2017
ISSN1097-4180
Abstract

A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

DOI10.1016/j.immuni.2017.02.005
Alternate JournalImmunity
PubMed ID28228277
PubMed Central IDPMC5357134
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
UM1 AI126603 / AI / NIAID NIH HHS / United States
U19 AI095985 / AI / NIAID NIH HHS / United States
U19 AI096040 / AI / NIAID NIH HHS / United States
UM1 AI124377 / AI / NIAID NIH HHS / United States
CHAVI-ID: 
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