|Title||Prospects for a Zika Virus Vaccine.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Barouch DH, Thomas SJ, Michael NL|
A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.
|PubMed Central ID||PMC5357134|
|Grant List||UM1 AI100663 / AI / NIAID NIH HHS / United States |
UM1 AI126603 / AI / NIAID NIH HHS / United States
U19 AI095985 / AI / NIAID NIH HHS / United States
U19 AI096040 / AI / NIAID NIH HHS / United States
UM1 AI124377 / AI / NIAID NIH HHS / United States
Prospects for a Zika Virus Vaccine.