Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.

TitleSequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.
Publication TypeJournal Article
Year of Publication2016
AuthorsReese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly R-P, Jameson SC, Masopust D, W Haining N, Virgin HW
JournalCell Host Microbe
Volume19
Issue5
Pagination713-9
Date Published2016 May 11
ISSN1934-6069
Abstract

Immune responses differ between laboratory mice and humans. Chronic infection with viruses and parasites are common in humans, but are absent in laboratory mice, and thus represent potential contributors to inter-species differences in immunity. To test this, we sequentially infected laboratory mice with herpesviruses, influenza, and an intestinal helminth and compared their blood immune signatures to mock-infected mice before and after vaccination against yellow fever virus (YFV-17D). Sequential infection altered pre- and post-vaccination gene expression, cytokines, and antibodies in blood. Sequential pathogen exposure induced gene signatures that recapitulated those seen in blood from pet store-raised versus laboratory mice, and adult versus cord blood in humans. Therefore, basal and vaccine-induced murine immune responses are altered by infection with agents common outside of barrier facilities. This raises the possibility that we can improve mouse models of vaccination and immunity by selective microbial exposure of laboratory animals to mimic that of humans.

DOI10.1016/j.chom.2016.04.003
Alternate JournalCell Host Microbe
PubMed ID27107939
PubMed Central IDPMC4896745
Grant ListR37 AI048638 / AI / NIAID NIH HHS / United States
R01 DK101354 / DK / NIDDK NIH HHS / United States
P30 CA077598 / CA / NCI NIH HHS / United States
U19 AI057266 / AI / NIAID NIH HHS / United States
R56 AI048638 / AI / NIAID NIH HHS / United States
R37 DK057665 / DK / NIDDK NIH HHS / United States
P30 AR048335 / AR / NIAMS NIH HHS / United States
R01 AI111918 / AI / NIAID NIH HHS / United States
R01 AI048638 / AI / NIAID NIH HHS / United States
R01 OD011170 / OD / NIH HHS / United States
R24 OD019793 / OD / NIH HHS / United States
CHAVI-ID: