A switch from canonical to noncanonical autophagy shapes B cell responses.

TitleA switch from canonical to noncanonical autophagy shapes B cell responses.
Publication TypeJournal Article
Year of Publication2017
AuthorsMartinez-Martin N, Maldonado P, Gasparrini F, Frederico B, Aggarwal S, Gaya M, Tsui C, Burbage M, Keppler SJessica, Montaner B, Jefferies HBJ, Nair U, Zhao YG, Domart M-C, Collinson L, Bruckbauer A, Tooze SA, Batista FD
JournalScience
Volume355
Issue6325
Pagination641-647
Date Published02/10/2017
ISSN1095-9203
Abstract

Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during viral infection. In contrast to mechanistic target of rapamycin complex 1-dependent canonical autophagy, GC B cell autophagy occurred predominantly through a noncanonical pathway. B cell stimulation was sufficient to down-regulate canonical autophagy transiently while triggering noncanonical autophagy. Genetic ablation of WD repeat domain, phosphoinositide-interacting protein 2 in B cells alone enhanced this noncanonical autophagy, resulting in changes of mitochondrial homeostasis and alterations in GC and antibody-secreting cells. Thus, B cell activation prompts a temporal switch from canonical to noncanonical autophagy that is important in controlling B cell differentiation and fate.

DOI10.1126/science.aal3908
Alternate JournalScience
PubMed ID28183981
Grant ListUM1 AI100663 / AI / NIAID NIH HHS / United States
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