Systems vaccinology: probing humanity's diverse immune systems with vaccines.

TitleSystems vaccinology: probing humanity's diverse immune systems with vaccines.
Publication TypeJournal Article
Year of Publication2014
AuthorsPulendran B
JournalProc Natl Acad Sci U S A
Volume111
Issue34
Pagination12300-6
Date Published08/26/2014
ISSN1091-6490
Abstract

Homo sapiens are genetically diverse, but dramatic demographic and socioeconomic changes during the past century have created further diversification with respect to age, nutritional status, and the incidence of associated chronic inflammatory disorders and chronic infections. These shifting demographics pose new challenges for vaccination, as emerging evidence suggests that age, the metabolic state, and chronic infections can exert major influences on the immune system. Thus, a key public health challenge is learning how to reprogram suboptimal immune systems to induce effective vaccine immunity. Recent advances have applied systems biological analysis to define molecular signatures induced early after vaccination that correlate with and predict the later adaptive immune responses in humans. Such "systems vaccinology" approaches offer an integrated picture of the molecular networks driving vaccine immunity, and are beginning to yield novel insights about the immune system. Here we discuss the promise of systems vaccinology in probing humanity's diverse immune systems, and in delineating the impact of genes, the environment, and the microbiome on protective immunity induced by vaccination. Such insights will be critical in reengineering suboptimal immune systems in immunocompromised populations.

DOI10.1073/pnas.1400476111
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID25136102
PubMed Central IDPMC4151766
Grant ListAI100663-02 / AI / NIAID NIH HHS / United States
R37AI48638 / AI / NIAID NIH HHS / United States
R37DK057665 / DK / NIDDK NIH HHS / United States
U19AI057266 / AI / NIAID NIH HHS / United States
U19AI090023 / AI / NIAID NIH HHS / United States
U54AI057157 / AI / NIAID NIH HHS / United States
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