The T-Cell Response to HIV.

TitleThe T-Cell Response to HIV.
Publication TypeJournal Article
Year of Publication2012
AuthorsWalker BD, McMichael A
JournalCold Spring Harb Perspect Med
Date Published2012 Sep 21
ISSN2157-1422
Abstract

HIV is a disease in which the original clinical observations of severe opportunistic infections gave the first clues regarding the underlying pathology, namely that HIV is essentially an infection of the immune system. HIV infects and deletes CD4(+) T cells that normally coordinate the adaptive T- and B-cell response to defend against intracellular pathogens. The immune defect is immediate and profound: At the time of acute infection with an AIDS virus, typically more than half of the gut-associated CD4(+) T cells are depleted, leaving a damaged immune system to contend with a life-long infection.

DOI10.1101/cshperspect.a007054
Alternate JournalCold Spring Harb Perspect Med
PubMed ID23002014