T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.

TitleT Follicular Helper Cell Biology: A Decade of Discovery and Diseases.
Publication TypeJournal Article
Year of Publication2019
AuthorsCrotty S
JournalImmunity
Volume50
Issue5
Pagination1132-1148
Date Published05/21/2019
ISSN1097-4180
Abstract

Helping B cells and antibody responses is a major function of CD4 T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4 T cells needed for germinal centers (the microanatomical sites of B cell mutation and antibody affinity maturation) and related B cell responses. A great deal has been learned about Tfh cells in the past 10 years, particularly regarding their roles in a surprising range of diseases. Advances in the understanding of Tfh cell differentiation and function are discussed, as are the understanding of Tfh cells in infectious diseases, vaccines, autoimmune diseases, allergies, atherosclerosis, organ transplants, and cancer. This includes discussion of Tfh cells in the human immune system. Based on the discoveries to date, the next decade of Tfh research surely holds many more surprises. VIDEO ABSTRACT.

DOI10.1016/j.immuni.2019.04.011
Alternate JournalImmunity
PubMed ID31117010
PubMed Central IDPMC6532429
Grant ListR01 AI135193 / AI / NIAID NIH HHS / United States
U19 AI109976 / AI / NIAID NIH HHS / United States
UM1 AI100663 / AI / NIAID NIH HHS / United States
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