T follicular helper cell differentiation, function, and roles in disease.

TitleT follicular helper cell differentiation, function, and roles in disease.
Publication TypeJournal Article
Year of Publication2014
AuthorsCrotty S
JournalImmunity
Volume41
Issue4
Pagination529-42
Date Published10/16/2014
ISSN1097-4180
KeywordsAnimals, Antibodies, B-Lymphocytes, DNA-Binding Proteins, Germinal Center, Hematopoiesis, Humans, Immunologic Memory, Interleukin-12 Subunit p35, Lymphocyte Activation, Mice, Signal Transduction, T-Lymphocytes, Helper-Inducer
Abstract

Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh cell biology, including their differentiation, migration, transcriptional regulation, and B cell help functions. Tfh cells are critical components of many protective immune responses against pathogens. As such, there is strong interest in harnessing Tfh cells to improve vaccination strategies. Tfh cells also have roles in a range of other diseases, particularly autoimmune diseases. Overall, there have been dramatic advances in this young field, but there is much to be learned about Tfh cell biology in the interest of applying that knowledge to biomedical needs.

DOI10.1016/j.immuni.2014.10.004
Alternate JournalImmunity
PubMed ID25367570
PubMed Central IDPMC4223692
Grant ListR01 AI063107 / AI / NIAID NIH HHS / United States
R01 AI072543 / AI / NIAID NIH HHS / United States
U19 AI090970 / AI / NIAID NIH HHS / United States
U19 AI109976 / AI / NIAID NIH HHS / United States
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