Towards HIV-1 remission: potential roles for broadly neutralizing antibodies.

TitleTowards HIV-1 remission: potential roles for broadly neutralizing antibodies.
Publication TypeJournal Article
Year of Publication2016
AuthorsHalper-Stromberg A, Nussenzweig MC
JournalJ Clin Invest
Volume126
Issue2
Pagination415-23
Date Published02/01/2016
ISSN1558-8238
Abstract

Current antiretroviral drug therapies do not cure HIV-1 because they do not eliminate a pool of long-lived cells harboring immunologically silent but replication-competent proviruses - termed the latent reservoir. Eliminating this reservoir and stimulating the immune response to control infection in the absence of therapy remain important but unsolved goals of HIV-1 cure research. Recently discovered broadly neutralizing antibodies (bNAbs) exhibit remarkable breadth and potency in their ability to neutralize HIV-1 in vitro, and recent studies have demonstrated new therapeutic applications for passively administered bNAbs in vivo. This Review discusses the roles bNAbs might play in HIV-1 treatment regimens, including prevention, therapy, and cure.

DOI10.1172/JCI80561
Alternate JournalJ. Clin. Invest.
PubMed ID26752643
PubMed Central IDPMC4731188
Grant ListAI100148-03 / AI / NIAID NIH HHS / United States
AI100663-04 / AI / NIAID NIH HHS / United States
AI109830-02 / AI / NIAID NIH HHS / United States
T32GM07739 / GM / NIGMS NIH HHS / United States
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