Using epigenetics to define vaccine-induced memory T cells.

TitleUsing epigenetics to define vaccine-induced memory T cells.
Publication TypeJournal Article
Year of Publication2013
AuthorsYoungblood B, J Hale S, Akondy R
JournalCurr Opin Virol
Date Published06/01/2013
ISSN1879-6265
Abstract

Memory T cells generated from acute infection or vaccination have the potential to provide the host with life-long immunity against re-infection. Protection by memory T cells is achieved through their acquired ability to persist at anatomical sites of the primary infection as well as maintaining a heightened ability to recall effector functions. The maintenance of CD8 and CD4 T cell function in a state of readiness is key to life-long immunity and manifest through changes in transcriptional regulation. Yet, the ability to identify poised transcriptional programs at the maintenance stage of the response is lacking from most transcriptional profiling studies of memory T cells. Epigenetic profiling allows for the assessment of transcriptionally poised (promoters that are readily accessible for transcription) states of antigen-specific T cells without manipulation of the activation state of the cell. Here we review recent studies that have examined epigenetic programs of effector and memory T cell subsets. These reports demonstrate that acquisition of epigenetic programs during memory T cell differentiation to acute and chronic infections is coupled to, and potentially regulate, the cell's recall response. We discuss the usefulness of epigenetic profiling in characterizing T cell differentiation state and function for preclinical evaluation of vaccines and the current methodologies for single locus versus genome-wide epigenetic profiling.

DOI10.1016/j.coviro.2013.05.017
Alternate JournalCurr Opin Virol
PubMed ID23747121
Grant ListR01 AI030048 / AI / NIAID NIH HHS / United States
U19 AI057266 / AI / NIAID NIH HHS / United States
UM1 AI100663 / AI / NIAID NIH HHS / United States
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