What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise.

TitleWhat Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise.
Publication TypeJournal Article
Year of Publication2017
AuthorsBurton DR
JournalCold Spring Harb Perspect Biol
Paginationpii:a030262
Date Published02/03/2017
ISSN1943-0264
Abstract

Functional antibodies, i.e., those with antipathogen activity in in vitro assays, are generally the best correlate of vaccine protection. Mimics of natural infection, including live attenuated and killed pathogens, which induce such antibodies in vivo, have generated highly successful vaccines. However, pathogens that induce functional antibodies at lower levels or more sporadically have been more refractory to vaccine design. Such pathogens are being tackled by more systematic approaches involving identifying functional antibodies, templating immunogens from the antibodies, and then evaluating the immunogens iteratively. I believe this is a powerful new approach to vaccine design as discussed below.

DOI10.1101/cshperspect.a030262
Alternate JournalCold Spring Harb Perspect Biol
PubMed ID28159875
PubMed Central IDPMC5540812
CHAVI-ID: 
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