Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.

TitleZika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.
Publication TypeJournal Article
Year of Publication2017
AuthorsAid M, Abbink P, Larocca RA, Boyd M, Nityanandam R, Nanayakkara O, Martinot AJ, Moseley ET, Blass E, Borducchi EN, Chandrashekar A, Brinkman AL, Molloy K, Jetton D, Tartaglia LJ, Liu J, Best K, Perelson AS, De La Barrera RA, Lewis MG, Barouch DH
JournalCell
Volume169
Issue4
Pagination610-620.e14
Date Published05/04/2017
ISSN1097-4172
Abstract

Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies correlated with rapid clearance of virus in peripheral blood but remained undetectable in CSF for the duration of the study. Viral persistence in both CSF and LN correlated with upregulation of mechanistic target of rapamycin (mTOR), proinflammatory, and anti-apoptotic signaling pathways, as well as downregulation of extracellular matrix signaling pathways. These data raise the possibility that persistent or occult neurologic and lymphoid disease may occur following clearance of peripheral virus in ZIKV-infected individuals.

DOI10.1016/j.cell.2017.04.008
Alternate JournalCell
PubMed ID28457610
PubMed Central IDPMC5426912
Grant ListR01 OD011095 / OD / NIH HHS / United States
UM1 AI100663 / AI / NIAID NIH HHS / United States
UM1 AI126603 / AI / NIAID NIH HHS / United States
R37 AI028433 / AI / NIAID NIH HHS / United States
U19 AI095985 / AI / NIAID NIH HHS / United States
R01 AI028433 / AI / NIAID NIH HHS / United States
U19 AI096040 / AI / NIAID NIH HHS / United States
R01 AI078881 / AI / NIAID NIH HHS / United States
R56 AI078881 / AI / NIAID NIH HHS / United States
UM1 AI124377 / AI / NIAID NIH HHS / United States
CHAVI-ID: 
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