Publications

Found 42 results
Filters: Author is Wyatt, Richard T  [Clear All Filters]
2017
Bale S, Goebrecht G, Stano A, Wilson R, Ota T, Tran K, Ingale J, Zwick MB, Wyatt RT.  2017.  Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses.. J Virol. 91(16):pii:e00443-17.
Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su C-Y, Sok D, Khan SN, Garces F et al..  2017.  Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.. Cell Rep. 21(1):222-235.
Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA et al..  2017.  Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.. Immunity. 46(6):1073-1088.e6.
Guenaga J, Garces F, de Val N, Stanfield RL, Dubrovskaya V, Higgins B, Carrette B, Ward AB, Wilson IA, Wyatt RT.  2017.  Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.. Immunity. 46(5):792-803.e3.
Wang Y, O'Dell S, Turner HL, Chiang C-I, Lei L, Guenaga J, Wilson R, Martinez-Murillo P, Doria-Rose N, Ward AB et al..  2017.  HIV-1 Cross-Reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Nonhuman Primates.. J Virol. 91(21)
Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, dori MÀ, Feng Y, Phad GE, Bernat NVázquez, Bale S, Ingale J et al..  2017.  Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach.. Immunity. 46(5):804-817.e7.
2016
Ingale J, Stano A, Guenaga J, Sharma SKumar, Nemazee D, Zwick MB, Wyatt RT.  2016.  High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.. Cell Rep. 15(9):1986-99.
Wang Y, Sundling C, Wilson R, O'Dell S, Chen Y, Dai K, Phad GE, Zhu J, Xiao Y, Mascola JR et al..  2016.  High-Resolution Longitudinal Study of HIV-1 Env Vaccine-Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence.. J Immunol.
Chen Y, Wilson R, O'Dell S, Guenaga J, Feng Y, Tran K, Chiang C-I, Arendt HE, DeStefano J, Mascola JR et al..  2016.  An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.. J Immunol. 197(10):3982-3998.
Dai K, Khan SN, Wang Y, He L, Guenaga J, Ingale J, Sundling C, O'Dell S, McKee K, Phad G et al..  2016.  HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation.. Sci Rep. 6:20987.
Kong L, Ju B, Chen Y, He L, Ren L, Liu J, Hong K, Su B, Wang Z, Ozorowski G et al..  2016.  Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.. Immunity. 44(4):939-50.
Feng Y, Tran K, Bale S, Kumar S, Guenaga J, Wilson R, de Val N, Arendt H, DeStefano J, Ward AB et al..  2016.  Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies.. PLoS Pathog. 12(8):e1005767.
2015
Sharma SKumar, de Val N, Bale S, Guenaga J, Tran K, Feng Y, Dubrovskaya V, Ward AB, Wyatt RT.  2015.  Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design.. Cell Rep.
Ingale J, Wyatt RT.  2015.  Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays.. Bio Protoc. 5(20)
Ingale J, Wyatt RT.  2015.  Kinetic Analysis of Monoclonal Antibody Binding to HIV-1 gp120-derived Hyperglycosylated Cores.. Bio Protoc. 5(20)
Martinez P, Sundling C, O'Dell S, Mascola JR, Wyatt RT, Karlsson Hedestam GB.  2015.  Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation.. Sci Rep. 5:8925.
Dai K, He L, Khan SN, O'Dell S, McKee K, Tran K, Li Y, Sundling C, Morris CD, Mascola JR et al..  2015.  Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis.. MBio. 6(6):e01375-15.
Guenaga J, Dubrovskaya V, de Val N, Sharma SK, Carrette B, Ward AB, Wyatt RT.  2015.  Structure-guided redesign increases the propensity of HIV Env to generate highly stable soluble trimers.. J Virol.
Crooks ET, Tong T, Chakrabarti B, Narayan K, Georgiev IS, Menis S, Huang X, Kulp D, Osawa K, Muranaka J et al..  2015.  Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.. PLoS Pathog. 11(5):e1004932.
Guenaga J, de Val N, Tran K, Feng Y, Satchwell K, Ward AB, Wyatt RT.  2015.  Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties.. PLoS Pathog. 11(1):e1004570.

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