Publications

Found 54 results
Filters: Author is Sanders, Rogier W  [Clear All Filters]
2017
Dey AK, Cupo A, Ozorowski G, Sharma VK, Behrens A-J, Go EP, Ketas TJ, Yasmeen A, Klasse PJ, Sayeed E et al..  2017.  cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate.. Biotechnol Bioeng.
Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H et al..  2017.  Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.. Sci Transl Med. 9(373):pii:eaa12144.
Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens A-J, Ozorowski G et al..  2017.  Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.. J Exp Med. 214(9):2573-2590.
Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA et al..  2017.  Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.. Immunity. 46(6):1073-1088.e6.
A de la Peña T, Julien J-P, de Taeye SW, Garces F, Guttman M, Ozorowski G, Pritchard LK, Behrens A-J, Go EP, Burger JA et al..  2017.  Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.. Cell Rep. 20(8):1805-1817.
Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A et al..  2017.  The microanatomic segregation of selection by apoptosis in the germinal center.. Science. 358(6360)
2016
Behrens A-J, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N et al..  2016.  Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.. Cell Rep.
Havenar-Daughton C, Reiss SM, Carnathan DG, Wu JE, Kendric K, de la Peña ATorrents, Kasturi SPai, Dan JM, Bothwell M, Sanders RW et al..  2016.  Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique.. J Immunol.
Havenar-Daughton C, Carnathan DG, de la Peña ATorrents, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL et al..  2016.  Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.. Cell Rep. 17(9):2195-2209.
van Gils MJ, van den Kerkhof TLGM, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW et al..  2016.  An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.. Nat Microbiol. 2:16199.
van den Kerkhof TLGM, de Taeye SW, Boeser-Nunnink BD, Burton DR, Kootstra NA, Schuitemaker H, Sanders RW, van Gils MJ.  2016.  HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds.. Retrovirology. 13(1):48.
McCoy LE, van Gils MJ, Ozorowski G, Messmer T, Briney B, Voss JE, Kulp DW, Macauley MS, Sok D, Pauthner M et al..  2016.  Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.. Cell Rep. 16(9):2327-38.
Klasse PJ, Labranche CC, Ketas TJ, Ozorowski G, Cupo A, Pugach P, Ringe RP, Golabek M, van Gils MJ, Guttman M et al..  2016.  Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.. PLoS Pathog. 12(9):e1005864.
Tam HHei, Melo MB, Kang M, Pelet JM, Ruda VM, Foley MH, Hu JK, Kumari S, Crampton J, Baldeon AD et al..  2016.  Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.. Proc Natl Acad Sci U S A. 113(43):E6639-E6648.
2015
Garces F, Lee J H, de Val N, de la Peña ATorrents, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP et al..  2015.  Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.. Immunity. 43(6):1053-63.
Lee J H, Leaman DP, Kim AS, de la Peña ATorrents, Sliepen K, Yasmeen A, Derking R, Ramos A, de Taeye SW, Ozorowski G et al..  2015.  Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.. Nat Commun. 6:8167.
Schiffner T, de Val N, Russell RA, de Taeye SW, de la Peña ATorrents, Ozorowski G, Kim HJ, Nieusma T, Brod F, Cupo A et al..  2015.  Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens.. J Virol. 90(2):813-28.
Kong L, de la Peña ATorrents, Deller MC, Garces F, Sliepen K, Hua Y, Stanfield RL, Sanders RW, Wilson IA.  2015.  Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.. Acta Crystallogr D Biol Crystallogr. 71(Pt 10):2099-108.
Derking R, Ozorowski G, Sliepen K, Yasmeen A, Cupo A, Torres JL, Julien J-P, Lee J H, van Montfort T, de Taeye SW et al..  2015.  Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer.. PLoS Pathog. 11(3):e1004767.
Julien J-P, Lee J H, Ozorowski G, Hua Y, de la Peña ATorrents, de Taeye SW, Nieusma T, Cupo A, Yasmeen A, Golabek M et al..  2015.  Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.. Proc Natl Acad Sci U S A.
Sliepen K, van Montfort T, Ozorowski G, Pritchard LK, Crispin M, Ward AB, Sanders RW.  2015.  Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer.. Biomolecules. 5(4):2919-34.
Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L et al..  2015.  HIV-1 neutralizing antibodies induced by native-like envelope trimers.. Science.

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