In our laboratory, we are interested in both the cellular and the molecular events that lead to the activation of B cells. We want to understand how these events affect the ability of B cells to produce antibodies. To do this, we work both in vivo and in vitro by combining state-of-the-art imaging technology with biochemistry and genetic models. For example: by following B cells in vivo we can better understand where and when they are activated (Carrasco & Batista 2007; Gaya et al. 2015). By tracking single B cell receptor (BCR) molecules we have shown how the cortical cytoskeleton network regulates receptor signalling (Mattila et al. 2013; Treanor et al. 2011; Treanor et al. 2010). Similarly, by studying actin regulators such as Cdc42 or Nck we have shown that they play a major role in B cell activation and antibody production (Burbage et al. 2014; Castello et al. 2013).
We have therefore been, and continue to work towards, a clearer understanding of B cell activation and antibody production at a cellular and molecular level with our innovative approach. This knowledge will aid us in the fight against infectious diseases and cancer.